Experimental investigation of ovine intervertebral disc units in longitudinal loading
نویسندگان
چکیده
منابع مشابه
Mechanical loading affects the energy metabolism of intervertebral disc cells.
Research has shown that mechanical loading affects matrix biosynthesis of intervertebral disc (IVD) cells; however, the pathway(s) to this effect is currently unknown. Cellular matrix biosynthesis is an energy demanding process. The objective of this study was to investigate the effects of static and dynamic compressive loading on energy metabolism of IVD cells. Porcine annulus fibrosus (AF) an...
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Spinal segments show non-linear behaviour under axial compression. It is unclear to what extent this behaviour is attributable to the different components of the segment. In this study, we quantified the separate contributions of vertebral bodies and intervertebral discs to creep of a segment. Secondly, we investigated the contribution of bone and osteochondral endplate (endplates including car...
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Background: A large proportion of patients presenting with lumbar disc disease are opium addicts in our region. It was, therefore, hypothesized that morphine might affect the intervertebral disc. We investigated the histological findings of morphine dependency on intervertebral discs in rat. Methods: Forty NMRI adult male rats (230-250 g) placed on ordinary diet and received aqueous solution of...
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The primary function of the disc is mechanical; therefore, degenerative changes in disc mechanics and the interactions between the annulus fibrosus (AF) and nucleus pulposus (NP) in nondegenerate and degenerate discs are important to functional evaluation. The disc experiences complex loading conditions, including mechanical interactions between the pressurized NP and the surrounding fiber-rein...
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OBJECTIVE To evaluate the remodeling of the extracellular matrix in intervertebral disc degeneration through the experimental model of intervertebral disc degeneration. METHODS The model of disc degeneration induction, using needle 20G and 360° rotation, was applied for 30 seconds between the 6(th)/7(th), and 8(th)/9(th) coccygeal vertebrae of Wistar rats. The intermediary level, between the ...
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ژورنال
عنوان ژورنال: PAMM
سال: 2009
ISSN: 1617-7061,1617-7061
DOI: 10.1002/pamm.200910021